FACC、FSCAI，主任医师、教授、博士生导师，心血管内科学科主任。江苏省突出贡献中青年专家，享受国家政府特殊津贴，中国医师协会微创医学分会副主任委员，中国医师协会心血管内科医师分会常务委员，海峡两岸医药卫生交流协会心血管病专业委员会常委，中国医疗保健国际交流促进会心血管病分会常务委员，中国高血压联盟常委，中华医学会心血管病学分会委员，中华医学会心血管学分会代谢学组副组长，中国医药教育协会基础与临床研究促进工作委员会常委，江苏省医师协会心血管内科医师分会会长，江苏省预防医学会心血管疾病预防与控制专业委员会主任委员，卫生部心血管介入技术冠心病培训基地主任，Circulation，Circulation Research，PNAS，J hypertension，ATVB，IJBM等SCI期刊的特约审稿人，兼任《中华高血压杂志》、《中国动脉硬化杂志》、《中华现代内科学杂志》等编委。擅长心血管危重病、冠心病、高血压、心力衰竭等疾病的诊治，在江苏省首先开展了冠心病介入诊断和治疗手术。在急诊PCI术、复杂冠脉介入诊疗、先天性心脏病介入治疗和危重复杂心血管病救治上有丰富的经验，是国内知名心血管病专家。先后主持国家科技部重点研发项目1项，国家自然科学基金项目研究6项，江苏省前沿引领技术基础研究专项前沿项目1项，其他省级科研项目20余项。发表论文350余篇，SCI收录170篇以上，其中两篇发表在《Circulation》杂志上，一篇发表在《Circulation Research》上，两篇论文发表在《Ann Intern Med》上，两篇发表在《Basic Res Cardiol》，研究成果被ESC、ACC、AHA等国际著名指南引用。先后获得“江苏省科技创新团队”、中华医学科技三等奖、中国杰出心血管病研究奖、江苏医学科技一等奖、江苏省新技术引进一等奖、江苏省科技进步二等奖、江苏省科技进步三等奖、南京市科技进步二等奖等多个奖项。

中国医师协会微创医学分会副主任委员，中国医师协会心血管内科医师分会常务委员，海峡两岸医药卫生交流协会心血管病专业委员会常委，中国医疗保健国际交流促进会心血管病分会常务委员，中国高血压联盟常委，中华医学会心血管病学分会委员，中华医学会心血管学分会代谢学组副组长，中国医药教育协会基础与临床研究促进工作委员会常委，江苏省医师协会心血管内科医师分会会长，江苏省预防医学会心血管疾病预防与控制专业委员会主任委员，卫生部心血管介入技术冠心病培训基地主任，Circulation，Circulation Research，PNAS，J hypertension，ATVB，IJBM等SCI期刊的特约审稿人，兼任《中华高血压杂志》、《中国动脉硬化杂志》、《中华现代内科学杂志》等编委。

1.         Xi Tan, Jing Zhang, Yongyuan Heng, Lin Chen, Yi Wang, Shaojun Wu, Xiaoli Liu,Biao Xu,Ziyi Yu,Rong Gu.Locally delivered hydrogels with controlled release of nanoscale exosomes promote cardiac repair after myocardial infarction.Journal of Controlled Release.2024,368:303-317.

2.         Yi Wang, Xiaoli Liu, Baochuan Wu, Xi Tan, Lin Chen, Heyu Chu, Zeyu Zhou, Xue Bao, Biao Xu and Rong Gu.Mediation effect analysis of lipoprotein levels on BMI and cardiovascular outcomes in patients with heart failure.BMC Cardiovascular Disorders.2024,24:553.

3.         Yuting Feng, Xue Bao, Jinxuan Zhao, Lina Kang, Xuan Sun, Biao Xu.MSC-Derived Exosomes Mitigate Myocardial Ischemia/Reperfusion Injury by Reducing Neutrophil Infiltration and the Formation of Neutrophil Extracellular Traps.International Journal of  Nanomedicine.2024,19:2071-2090.

4.         Ying Tan, Xun Wang, Yu Gu, Xue Bao, He Lu, Xuan Sun, Lina Kang & Biao Xu.Neutrophil and Endothelial Cell Membranes Coassembled Roflumilast Nanoparticles Attenuate MI/R Injury. Nanomedicine. 2024, 19(9), 779–797.

5.         Xue Bao, Yu Mao, Guangxiang Si, Lina Kang, Biao Xu, and Ning Gu.Iron oxide nanoparticles: A promising approach for diagnosis andtreatment of cardiovascular diseases.Nano Research.2023,16(11):12453−12470.

6.         Jinxuan Zhao, Wei Cheng, Yang Dai, Yao Li, Yuting Feng, Ying Tan, Qiucang Xue, Xue Bao, Xuan Sun,Lina Kang, Dan Mu and Biao Xu.Excessive accumulation of epicardial adipose tissue promotes microvascular obstruction formation after myocardial ischemia/reperfusion through modulating macrophages polarization.Cardiovascular Diabetology.2024,23(1):236.

7.         Chenyi Gong, Lei Chang, Rong Huang, Xuan Sun,Yihai Liu, Shaojun Wu, Lintao Wang, Biao Xu,Lian Wang.LIM kinase 2 activates cardiac fibroblasts and exacerbates postinfarction left ventricular remodeling via crosstalk between the canonical and non-canonical Wnt pathways.Pharmacological Research.2024;208(0):107347.

8.         Song Shen, Jianhui Li, Zhonghai Wei, Yihai Liu, Lina Kang, Rong Gu, Xuan Sun, Biao Xu and QiaoLing Li.Immune-response gene 1 deficiency aggravates inflammation-triggered cardiac dysfunction by inducing M1 macrophage polarization and aggravating Ly6Chigh monocyte recruitment.Biology Direct.2024,19(1):86.

9.         Jiang, C., Shi, Q., Yang, J., Ren, H., Zhang, L., Chen, S., Si, J., Liu, Y., Sha, D., Xu, B., Ni, J. (2023). Ceria Nanozyme Coordination with Curcumin for Treatment of Sepsis-induced Cardiac Injury by Inhibiting Ferroptosis and Inflammation. J Adv Res.

10.     Wang, J., Tan, Y., Dai, Y., Hu, K., Tan, X., Jiang, S., Li, G., Zhang, X., Kang, L., Wang, X., Xu, B. (2023). Intranasal Delivery of Endothelial Cell-Derived Extracellular Vesicles with Supramolecular Gel Attenuates Myocardial Ischemia-Reperfusion Injury. Int J Nanomedicine. 18, 5495-5510.

11.     Chang, L., Huang, R., Chen, J., Li, G., Shi, G., Xu, B., Wang, L. (2023). An alpha-helix variant p.Arg156Pro in LMNA as a cause of hereditary dilated cardiomyopathy: genetics and bioinfomatics exploration. BMC Med Genomics. 16, 229.

12.     Sun, X., Feng, Y., Gong, C., Bao, X., Wei, Z., Chang, L., Chen, H., Xu, B. (2023). Hypertension-Driven Regulatory T-Cell Perturbations Accelerate Myocardial Ischemia-Reperfusion Injury. Hypertension. 80, 2046-2058.

13.     Wu, M., Si, J., Liu, Y., Kang, L., Xu, B. (2023). Association between composite dietary antioxidant index and hypertension: insights from NHANES. Clin Exp Hypertens. 45, 2233712.

14.     Wei, X., Mao, Y., Chen, Z., Kang, L., Xu, B., Wang, K. (2023). Exercise-induced myocardial hypertrophy preconditioning promotes fibroblast senescence and improves myocardial fibrosis through Nrf2 signaling pathway. Cell Cycle. 22, 1529-1543.

15.     Li, Z., Jia, J., Hao, H., Qiao, S., Zhang, Q., Zhang, X., Qi, Y., Sun, X., Wang, K., Gu, R., Kang, L., Xu, B. (2023). Anti-Diabetic Drugs Inhibit Bulimia Induced Obesity. Front Biosci (Landmark Ed). 28, 97.

16.     Wu, M., Liao, S., Si, J., Guo, X., Kang, L., Xu, B., Liu, Y. (2023). Association of low-density lipoprotein-cholesterol with all-cause and cause-specific mortality. Diabetes Metab Syndr. 17, 102784.

17.     Bao, X., Xu, B., Lind, L., Engstrom, G. (2023). Carotid ultrasound and systematic coronary risk assessment 2 in the prediction of cardiovascular events. Eur J Prev Cardiol. 30, 1007-1014.

18.     Xie, J., Jiang, L., Wang, J., Yin, Y., Wang, R., Du, L., Chen, T., Ni, Z., Qiao, S., Gong, H., Xu, B., Xu, Q. (2023). Multilineage contribution of CD34(+) cells in cardiac remodeling after ischemia/reperfusion injury. Basic Res Cardiol. 118, 17.

19.     Yin, X. Y., Zhang, Y. M., Shen, A. D., Wang, J. P., Lian, Z. X., Shao, Y. B., Zhang, W. Q., Zhang, S. Y., Zheng, Y., Cheng, K., Xu, B., Shen, C. X., Huang, R. C., Guo, J. C., Fu, G. S., Shan, D. K., Li, D. D., Chen, Y. D. (2023). Evaluation of metoprolol standard dosing pathway in Chinese patients with acute coronary syndrome: a prospective multicenter single-arm interventional study. J Geriatr Cardiol. 20, 256-267.

20.     Hao, H., Li, Z., Qiao, S. Y., Qi, Y., Xu, X. Y., Si, J. Y., Liu, Y. H., Chang, L., Shi, Y. F., Xu, B., Wei, Z. H., Kang, L. N. (2023). Empagliflozin ameliorates atherosclerosis via regulating the intestinal flora. Atherosclerosis. 371, 32-40.

21.     Hu, J., Xu, J., Tan, X., Li, D., Yao, D., Xu, B., Lei, Y. (2023). Dapagliflozin protects against dilated cardiomyopathy progression by targeting NLRP3 inflammasome activation. Naunyn Schmiedebergs Arch Pharmacol. 396, 1461-1470.

22.     Huang, R., Zhang, X., Han, Z., Wu, X., Li, G., Chen, J., Xu, B., Gu, R., Wang, L. (2023). Refractory ventricular tachycardia and heart failure due to anti-mitochondrial antibody-positive inflammatory myopathy. BMC Cardiovasc Disord. 23, 57.

23.     Zhao, J., Zhang, Q., Cheng, W., Dai, Q., Wei, Z., Guo, M., Chen, F., Qiao, S., Hu, J., Wang, J., Chen, H., Bao, X., Mu, D., Sun, X., Xu, B., Xie, J. (2023). Heart-gut microbiota communication determines the severity of cardiac injury after myocardial ischaemia/reperfusion. Cardiovasc Res. 119, 1390-1402.

24.     Duan, J., Liu, X., Shen, S., Tan, X., Wang, Y., Wang, L., Kang, L., Wang, K., Wei, Z., Qi, Y., Hu, L., Xu, B., Gu, R. (2023). Trophoblast Stem-Cell-Derived Exosomes Alleviate Cardiotoxicity of Doxorubicin via Improving Mfn2-Mediated Mitochondrial Fusion. Cardiovasc Toxicol. 23, 23-31.

25.     Liu, Y., Chang, L., Wu, M., Xu, B., Kang, L. (2023). Triglyceride Glucose Index Was Associated With the Risk of Peripheral Artery Disease: Reply. Angiology. 74, 298.

26.     Wang, K., Qi, Y., Gu, R., Dai, Q., Shan, A., Li, Z., Gong, C., Chang, L., Hao, H., Duan, J., Xu, J., Hu, J., Mu, D., Zhang, N., Lu, J., Wang, L., Wu, H., Li, L., Kang, L., Xu, B. (2022). Renal Denervation Attenuates Adverse Remodeling and Intramyocardial Inflammation in Acute Myocardial Infarction With Ischemia-Reperfusion Injury. Frontiers in cardiovascular medicine, 9, 832014.

27.     Huang, R., Dai, Q., Chang, L., Wang, Z., Chen, J., Gu, R., Zheng, H., Hu, L., Xu, B., Wang, L. (2022). The association between fibrinogen-to-albumin ratio (FAR) and adverse prognosis in patients with acute decompensated heart failure at different glucose metabolic states. Cardiovascular diabetology, 21(1), 241.

28.     [3]Gong, C., Chang, L., Sun, X., Qi, Y., Huang, R., Chen, K., Wang, B., Kang, L., Wang, L., Xu, B. (2022). Infusion of two-dose mesenchymal stem cells is more effective than a single dose in a dilated cardiomyopathy rat model by upregulating indoleamine 2,3-dioxygenase expression. Stem cell research therapy, 13(1), 409.

29.     Chang, L., Gong, C., Lu, H., Liu, Y., Kang, L., Chen, J., Wang, L., Xu, B. (2022). Percutaneous intravenous catheter forceps biopsy in right atrial mass: two case reports and literature review. BMC cardiovascular disorders, 22(1), 63.

30.     Sun, X., Duan, J., Gong, C., Feng, Y., Hu, J., Gu, R., Xu, B. (2022). Colchicine Ameliorates Dilated Cardiomyopathy Via SIRT2-Mediated Suppression of NLRP3 Inflammasome Activation. Journal of the American Heart Association, 11(13), e025266.

31.     Shen, S., Duan, J., Hu, J., Qi, Y., Kang, L., Wang, K., Chen, J., Wu, X., Xu, B., Gu, R. (2022). Colchicine alleviates inflammation and improves diastolic dysfunction in heart failure rats with preserved ejection fraction. European journal of pharmacology, 929, 175126.

32.     Qi, Y., Chen, J., Duan, J., Kang, L., Wang, K., Chen, Z., Xu, B., Gu, R. (2022). Major vault protein attenuates cardiomyocyte injury in doxorubicin-induced cardiomyopathy through activating AKT. BMC cardiovascular disorders, 22(1), 77.

33.     Shen, S., Yan, X., Xu, B. (2022). The blood urea nitrogen/creatinine (BUN/cre) ratio was U-shaped associated with all-cause mortality in general population. Renal failure, 44(1), 184–190.

34.     Zhang, X. L., Wang, T. Y., Chen, Z., Wang, H. W., Yin, Y., Wang, L., Wang, Y., Xu, B., Xu, W. (2022). HMGB1-Promoted Neutrophil Extracellular Traps Contribute to Cardiac Diastolic Dysfunction in Mice. Journal of the American Heart Association, 11(4), e023800.

35.     Zhang, X. L., Wei, Z. H., Wang, H. W., Xu, W., Wang, Y., Xu, B. (2022). Early and midterm outcomes of transcatheter aortic-valve replacement with balloon-expandable versus self-expanding valves: A meta-analysis. Journal of cardiology, 80(3), 204–210.

36.     Liu, Y., Wu, M., Zhong, C., Xu, B., Kang, L. (2022). M2-like macrophages transplantation protects against the doxorubicin-induced heart failure via mitochondrial transfer. Biomaterials research, 26(1), 14.

37.     Bao, X., Xu, B., Muhammad, I. F., Nilsson, P. M., Nilsson, J., Engström, G. (2022). Plasma prostasin: a novel risk marker for incidence of diabetes and cancer mortality. Diabetologia, 65(10), 1642–1651.

38.     Zhao, J., Cheng, W., Lu, H., Shan, A., Zhang, Q., Sun, X., Kang, L., Xie, J., Xu, B. (2022). High fiber diet attenuate the inflammation and adverse remodeling of myocardial infarction via modulation of gut microbiota and metabolites. Frontiers in microbiology, 13, 1046912.

39.     Zhang, W., Chen, Z., Qiao, S., Chen, S., Zheng, H., Wei, X., Li, Q., Xu, B., Huang, W. (2022). The effects of extracellular vesicles derived from Krüppel-Like Factor 2 overexpressing endothelial cells on the regulation of cardiac inflammation in the dilated cardiomyopathy. Journal of nanobiotechnology, 20(1), 76.

40.     Liu, Y., Chang, L., Wu, M., Xu, B., Kang, L. (2022). Triglyceride Glucose Index Was Associated With the Risk of Peripheral Artery Disease. Angiology, 73(7), 655–659.

41.     Hu, J., Zhang, Y., Hu, L., Chen, H., Wu, H., Chen, J., Xie, J., Xu, B., Wei, Z. (2022). A reduction of Syndecan-4 in macrophages promotes atherosclerosis by aggravating the proinflammatory capacity of macrophages. Journal of translational medicine, 20(1), 319.

42.     Liu, Y., Wu, M., Xu, B., Kang, L. (2022). Association between the urinary nickel and the diastolic blood pressure in general population. Chemosphere, 286(Pt 3), 131900.

43.     Zhang XL, Zhang XW, Lan RF, Chen Z, Wang L, Xu W, Xu B. Long-term and Temporal Outcomes of Transcatheter Versus Surgical Aortic-valve Replacement in Severe Aortic Stenosis: A Meta-analysis. Ann Surg, 2021, 273 (3): 459-66. IF= 12.969

44.     Jiaxin Hu, Yuyu Li, Zhonghai Wei, Haiting Chen， Xuan Sun，Qing Zhou，Qi Zhang，Yong Yin，Meng Guo， Jianzhou Chen，Guangyao Zhai， Biao Xu， Jun Xie .A reduction in the vascular smooth muscle cell focal adhesion component syndecan-4 is associated with abdominal aortic aneurysm formation，Clinical and Translational Medicine，2021 Dec;11(12):e605. IF=11.492

45.     Mu D, Wang W, Li J, Lv P, Liu R, Tan Y, Zhong C, Qi Y, Sun X, Liu Y, Shen S, Li Y, Xu B, Zhang B. Ultrasmall Fe(III)-Tannic Acid Nanoparticles To Prevent Progression of Atherosclerotic Plaques. ACS Appl Mater Interfaces, 2021, 13 (29): 33915-25. IF =9.229

46.     Wei Z, Yang Y, Li Q, Yin Y, Wei Z, Zhang W, Mu D, Ni J, Sun X, Xu B. The transcriptome of circulating cells indicates potential biomarkers and therapeutic targets in the course of hypertension-related myocardial infarction. Genes Dis, 2021, 8 (4): 555-68. IF= 7.103

47.     Wei Z, Chen Z, Zhao Y, Fan F, Xiong W, Song S, Yin Y, Hu J, Yang K, Yang L, Xu B, Ge J. Mononuclear phagocyte system blockade using extracellular vesicles modified with CD47 on membrane surface for myocardial infarction reperfusion injury treatment. Biomaterials, 2021, 275: 121000. IF=12.479

48.     Liu Y, Wu M, Xu B, Kang L. Association between the urinary nickel and the diastolic blood pressure in general population. Chemosphere, 2021, 286 (Pt 3): 131900. IF=7.086

49.     Liu Y, Wu M, Xu B, Kang L. Empagliflozin Alleviates Atherosclerosis Progression by Inhibiting Inflammation and Sympathetic Activity in a Normoglycemic Mouse Model. J Inflamm Res, 2021, 14: 2277-87. IF=6.922

50.     Liu Y, Xu J, Wu M, Xu B, Kang L. Empagliflozin protects against atherosclerosis progression by modulating lipid profiles and sympathetic activity. Lipids Health Dis, 2021, 20 (1): 5. IF=3.876

51.     Liu Y, Wu M, Xu J, Xu B, Kang L. Empagliflozin prevents from early cardiac injury post myocardial infarction in non-diabetic mice. Eur J Pharm Sci, 2021, 161: 105788. IF=4.384

52.     Li Y, Zhang Y, Lu J, Yin Y, Xie J, Xu B. Anti-inflammatory mechanisms and research progress of colchicine in atherosclerotic therapy. J Cell Mol Med, 2021. IF= 5.31

53.     Chen Z, Li R, Pei LG, Wei ZH, Xie J, Wu H, Xu B. High-mobility group box-1 promotes vascular calcification in diabetic mice via endoplasmic reticulum stress. J Cell Mol Med, 2021, 25 (8): 3724-34. IF=5.31

54.     Zhang XL, Xie J, Lan RF, Kang LN, Wang L, Xu W, Xu B. Genetic Basis and Genotype-Phenotype Correlations in Han Chinese Patients with Idiopathic Dilated Cardiomyopathy. Sci Rep, 2020, 10 (1): 2226. IF=4.379

55.     Zhang X, Wang T, Lan R, Dai Q, Kang L, Wang L, Wang Y, Xu W, Xu B. Meta-Analysis Comparing Results of Transcatheter Versus Surgical Aortic-Valve Replacement in Patients With Severe Aortic Stenosis. Am J Cardiol, 2020, 125 (3): 449-58. IF=2.778

56.     Bao X, Borne Y, Xu B, Orho-Melander M, Nilsson J, Melander O, Engstrom G. Growth differentiation factor-15 is a biomarker for all-cause mortality but less evident for cardiovascular outcomes: A prospective study. Am Heart J, 2021, 234: 81-9.  IF=4.749

57.     Wu M, Liu Y, Zhong C, Xu B, Kang L. Osteoporosis was associated with severe abdominal aortic calcification based on a cross-sectional study. Arch Osteoporos, 2021, 16 (1): 79. IF=2.617

58.     Lei D, Xie J, Dai Q, Huang Y, Wei X, Mu D, Bao X, Li J, Xu B. Prognostic relevance and clinical features of papillary muscle infarction with mitral regurgitation in patients with ST segment elevation myocardial infarction. J Thorac Dis, 2021, 13 (1): 334-42. IF=2.895

59.     Huang Y, Lei D, Chen Z, Xu B. Factors associated with microvascular occlusion in patients with ST elevation myocardial infarction after primary percutaneous coronary intervention. J Int Med Res, 2021, 49 (6): 3000605211024490. IF=1.671

60.     Hu T, Zhu P, Liu Y, Zhu H, Geng J, Wang B, Yuan G, Peng Y, Xu B. PM2.5 induces endothelial dysfunction via activating NLRP3 inflammasome. Environ Toxicol, 2021. IF=4.119

61.     Xu J, Li Z, Liu Y, Zhang X, Niu F, Zheng H, Wang L, Kang L, Wang K, Xu B. Danon disease: a case report and literature review. Diagn Pathol, 2021, 16 (1): 39. IF=2.644

62.     Liu Y, Zhang W, Hu T, Ni J, Xu B, Huang W. A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo. J Vis Exp, 2020. IF=1.355

63.     Wu H, Li R, Wang K, Mu D, Chen JZ, Wei X, Bao X, Wei ZH, Xie J, Xu B. Predictive Value of Fasting Blood Glucose for Microvascular Obstruction in Nondiabetic Patients with ST-Segment Elevation Myocardial Infarction after Primary Percutaneous Coronary Intervention. Cardiol Res Pract, 2020, 2020: 8429218. IF= 1.866

64.     Liu Y, Xu J, Wu M, Kang L, Xu B. The effector cells and cellular mediators of immune system involved in cardiac inflammation and fibrosis after myocardial infarction. J Cell Physiol, 2020, 235 (12): 8996-9004. IF=6.384

65.     Liu Y, Xu J, Gu R, Li Z, Wang K, Qi Y, Sun X, Xie J, Wang L, Xu B, Kang L. Circulating exosomal miR-144-3p inhibits the mobilization of endothelial progenitor cells post myocardial infarction via regulating the MMP9 pathway. Aging (Albany NY), 2020, 12 (16): 16294-303. IF=5.682

66.     Xuan Sun， Zilun Wei ， Yuyu Li， Junzhuo Wang，Jiaxin Hu，Yong Yin，Jun Xie，Biao Xu .Renal denervation restrains the inf ammatory response in myocardial ischemia–reperfusion injury.Basic Research In Cardiology， (2020) 115:15. （IF=17.165）

67.     Junzhuo Wang，Ziwei Chen，Qing Dai，Jinxuan Zhao，Zilun Wei，Jiaxin Hu，Xuan Sun，Jun Xie，Biao Xu.Intravenously delivered mesenchymal stem cells prevent microvascular obstruction formation after myocardial ischemia/reperfusion injury.Basic Research In Cardiology， (2020) 115:40. （IF=17.165）

68.     Ni J, Liu Y, Kang L, Wang L, Han Z, Wang K, Xu B, Gu R. Human trophoblast-derived exosomes attenuate doxorubicin-induced cardiac injury by regulating miR-200b and downstream Zeb1. J Nanobiotechnology, 2020, 18 (1): 171.  IF=10.435

69.     Ni J, Liu Y, Wang K, Wu M, Kang L, Sha D, Xu B, Gu R. Trophoblast Stem-Cell-Derived Exosomes Improve Doxorubicin-Induced Dilated Cardiomyopathy by Modulating the let-7i/YAP Pathway. Mol Ther Nucleic Acids, 2020, 22: 948-56.IF=8.886

70.     Ni J, Liu Y, Wu M, Wang J, Sha D, Xu B. Shock on Admission as a Potential Marker for ICU Mortality of Cardiac Arrest Patients. Int Heart J, 2020, 61 (4): 795-8.IF=1.862

71.     Zilun Wei, Yining Yang ,Qiaoling Li, Yong Yin，Zhonghai Wei, Wenfeng Zhang, Dan Mu,Jie Ni，Xuan Sun,Biao Xu.The transcriptome of circulating cells indicates potential biomarkers and therapeutic targets in the course of hypertension-related myocardial infarction.Genes Diseases，2020（IF=4.803）

72.     Qiao S, Zhang W, Yin Y, Wei Z, Chen F, Zhao J, Sun X, Mu D, Xie J, Xu B. Extracellular vesicles derived from Kruppel-Like Factor 2-overexpressing endothelial cells attenuate myocardial ischemia-reperfusion injury by preventing Ly6C(high) monocyte recruitment. Theranostics, 2020, 10 (25): 11562-79.  IF=11.556

73.     Qiao S, Zhang J, Kong Z, Wu H, Gu R, Zheng H, Xu B, Wei Z. Comparison of the prognosis for different onset stage of cardiogenic shock secondary to ST-segment elevation myocardial infarction. BMC Cardiovasc Disord, 2020, 20 (1): 302.  IF=2.298

74.     Mu D, Li J, Qi Y, Sun X, Liu Y, Shen S, Li Y, Xu B, Zhang B. Hyaluronic acid-coated polymeric micelles with hydrogen peroxide scavenging to encapsulate statins for alleviating atherosclerosis. J Nanobiotechnology, 2020, 18 (1): 179.IF=10.435

75.     Liu Y, Wei X, Wu M, Xu J, Xu B, Kang L. Cardioprotective Roles of beta-Hydroxybutyrate Against Doxorubicin Induced Cardiotoxicity. Front Pharmacol, 2020, 11: 603596.IF=5.81

76.     Liu Y, Wu M, Xu J, Sha D, Xu B, Kang L. Association between Triglyceride and glycose (TyG) index and subclinical myocardial injury. Nutr Metab Cardiovasc Dis, 2020, 30 (11): 2072-6. IF=4.222

77.     Liu Y, Xu J, Gu R, Li Z, Wang K, Qi Y, Sun X, Xie J, Wang L, Xu B, Kang L. Circulating exosomal miR-144-3p inhibits the mobilization of endothelial progenitor cells post myocardial infarction via regulating the MMP9 pathway. Aging (Albany NY), 2020, 12 (16): 16294-303.IF=5.682

78.     Liu Y, Xu J, Wu M, Kang L, Xu B. The effector cells and cellular mediators of immune system involved in cardiac inflammation and fibrosis after myocardial infarction. J Cell Physiol, 2020, 235 (12): 8996-9004.IF=6.384

79.     Liu Y, Zhang W, Hu T, Ni J, Xu B, Huang W. A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo. J Vis Exp, 2020, (159).IF=1.355

80.     Liu C, Kang LN, Chen F, Mu D, Shen S, Wang K, Hu JX, Xie J, Xu B. Immediate Intracoronary Delivery of Human Umbilical Cord Mesenchymal Stem Cells Reduces Myocardial Injury by Regulating the Inflammatory Process Through Cell-Cell Contact with T Lymphocytes. Stem Cells Dev, 2020, 29 (20): 1331-45.IF=3.272

81.     Chen F, Li X, Zhao J, Geng J, Xie J, Xu B. Bone marrow mesenchymal stem cell-derived exosomes attenuate cardiac hypertrophy and fibrosis in pressure overload induced remodeling. In Vitro Cell Dev Biol Anim, 2020, 56 (7): 567-76.IF=2.416

82.     Zhao J, Li X, Hu J, Chen F, Qiao S, Sun X, Gao L, Xie J, Xu B. Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization. Cardiovasc Res, 2019, 115 (7): 1205-16.（IF=10.787）

83.     Hai Cheng,, Yuhan Chen, Xueling Li, Fu Chen, Jinxuan Zhao,Jiaxin Hu, Anqi Shan, Shuaihua Qiao,Zilun Wei, Guixin He and Biao Xu. Involvement of Apelin/APJ Axis in Thrombogenesis in Value Heart Disease Patient with Atrial Fibrillation.International Heart Journal.2019,60(1):145-150（IF=1.862）

84.     Wei Zilun, Qiao Shuaihua, Zhao Jinxuan, Liu Yihai, Li Qiaoling, Wei Zhonghai,Dai Qing, Kang Lina, Xu Biao.miRNA-181a over-expression in mesenchymal stem cell-derived exosomes influenced inflammatory response after myocardial ischemia-reperfusion injury.Life Sciences.2019 Sep 1;232:116632.(IF=5.037)

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86.     Zhang XL, Lan RF, Zhang XW, Xu W, Wang L, Kang LN, Xu B. Association Between Baseline, Achieved, and Reduction of CRP and Cardiovascular Outcomes After LDL Cholesterol Lowering with Statins or Ezetimibe: A Systematic Review and Meta-Analysis. J Am Heart Assoc, 2019, 8 (16): e012428.（IF=5.501）

87.     Xinlin Zhang, Tingyu Wang, Rongfang Lan , Qing Dai , Lina Kang , Lian Wang , Yong Wang , Wei Xu , Biao Xu .Meta-Analysis Comparing Results of Transcatheter Versus Surgical Aortic-Valve Replacement in Patients WithSevereAortic Stenosis.Am J Cardiol.00:1−10.（IF=2.843）

88.     Xueling Li, Jinxuan Zhao, Jin Geng, Fu Chen , Zilun Wei , Chen Liu , Xinlin Zhang , Qiaoling Li , Jingmei Zhang , Ling Gao, Jun Xie, Biao Xu .Long non-coding RNA MEG3 knockdown attenuates endoplasmic reticulum stress-mediated apoptosis by targeting p53 following myocardial infarction.J Cell Mol Med.2019 Dec;23(12):8369-8380.（IF=5.31）

89.     Jin Geng, Haiyun Liu , Peibing Ge , Tingting Hu, Yanchun Zhang, Xiwen Zhang, Biao Xu , Bingjian Wang, Jun Xie . PM2.5 promotes plaque vulnerability at different stages of atherosclerosis and the formation of foam cells via TLR4/MyD88/NFκB pathway.Ecotoxicol Environ Saf.2019 Jul 30;176:76-84.（IF=6.291）

90.     Qinhua Chen, Ryan C Gimple, Guannan Li, Jianzhou Chen, Han Wu, Ran Li, Jun Xie, Biao Xu .LIM kinase 1 acts as a profibrotic mediator in permanent atrial fibrillation patients with valvular heart disease. J Biosci.2019 Mar;44(1). pii: 16.（IF=1.826）

91.     Kun Wang, Jingmei Zhang , Ning Zhang , Yu Shen, Lian Wang, Rong Gu, Biao Xu, Yong Ji  Combined Primary PCI with Multiple Thrombus Burden Reduction Therapy Improved Cardiac Function in Patients with Acute Anterior Myocardial Infarction.Int Heart J.2019 Jan 25;60(1):27-36.（IF=2.226）

92.     Zilun Wei, Yihai Liu, Shuaihua Qiao, Xueling Li , Qiaoling Li , Jinxuan Zhao , Jiaxin Hu , Zhonghai Wei, Anqi Shan , Xuan Sun , Biao Xu . Identification of the potential therapeutic target gene UBE2C in human hepatocellular carcinoma: An investigation based on GEO and TCGA databases.Oncology Letters.2019;17(6):5409-5418.（IF= 2.967）

93.     Han Wu, Zheng Chen, Jian-Zhou Chen, Jun Xie, and Biao Xu.Resveratrol Improves Tube Formation in AGE-Induced Late Endothelial Progenitor Cells by Suppressing Syndecan-4 Shedding. Oxid Med Cell Longev. 2018; 2018: 9045976.

94.     Jun X, Jin G, Fu C, Jinxuan Z, Xuelin L, Jiaxin H, Shuaihua Q, Anqi S, Jianzhou C, Lian Z, Xiwen Z, Baoli Z, Biao X.PM2.5 promotes abdominal aortic aneurysm formation in angiotensin Ⅱ-infused apoe-/- mice. Biomed Pharmacother. 2018 Aug;104:550-557. 

95.     Wei ZH, Dai Q, Wu H, Song J, Wang L, Xu B.Takotsubo cardiomyopathy after pacemaker implantation.J Geriatr Cardiol. 2018 Mar;15(3):246-248.

96.     Wang K, Shen Y, Li PW, Gu R, Zhang JM, Wang L, Bai J, Xu B.ST-Segment Elevation Myocardial Infarction Patients Complicated by Out-of-Hospital Cardiac Arrest May Not Benefit from Emergency Percutaneous Intervention.Chin Med J (Engl). 2018 Mar 20;131(6):746-747.

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104.  Xin-Lin Zhang, Qing-Qing Zhu, Li-Na Kang, Xue-Ling Li, and Biao Xu.Mid- and Long-Term Outcome Comparisons of Everolimus-Eluting Bioresorbable Scaffolds Versus Everolimus-Eluting Metallic Stents: A Systematic Review and Meta-analysis.Annals of Internal Medicine.2017，167（9）：642-654.

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106.  Guannan Li, Jun Xie, Jianzhou Chen, Ran Li, Han Wu, Xinlin Zhang, Qinhua Chen, Rong Gu , Biao Xu.Syndecan-4 deficiency accelerates the transition from compensated hypertrophy to heart failure following pressure overload.Cardiovascular Pathology.May-June，2017 Volume 28，Pages74–79.

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108.  Jun Xie, Yuhan Chen, Chuanxian Hu, Quanhua Pan, Bingjian Wang, Xueling Li, Jin Gengand Biao Xu.Premature senescence of cardiac fibroblasts and atrial fibrosis in patients with atrial fibrillation. Oncotarget. 2017, 8(35)：57981-57990.

109.  Xueling Li, Jin Geng, Yuhan Chen, Fu Chen, Chen Liu, Qiwen Xu, Jinxuan Zhao,Jiaxin Hu, Jun Xie, Biao Xu.Exposure to particulate matter induces cardiomyocytes apoptosis after myocardial infarction through NFkB activation.Biochem Biophys Res Commun.2017 Jun 17;488(1):224-231.

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172.  Mega JL, Braunwald E, Wiviott SD, Bassand JP, Bhatt DL, Bode C, Burton P, Cohen M, Cook-Bruns N, Fox KA, Goto S, Murphy SA, Plotnikov AN, Schneider D, Sun X, Xu B, Et.al. Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med. 2012 Jan 5;366(1):9-19.

173.  L. Ling, Y. Shen, K. Wang, C. Jiang, C. Fang, A. Ferro, L. Kang, and B. Xu, 'Worse Clinical Outcomes in Acute Myocardial Infarction Patients with Type 2 Diabetes Mellitus: Relevance to Impaired Endothelial Progenitor Cells Mobilization', PLoS One, 2012;7(11):e50739.

174.  R. Li, G. Yan, Q. Li, H. Sun, Y. Hu, J. Sun, and B. Xu, 'Microrna-145 Protects Cardiomyocytes against Hydrogen Peroxide (H₂O₂)-Induced Apoptosis through Targeting the Mitochondria Apoptotic Pathway', PLoS One, 2012;7(9):e44907. doi: 10.1371/journal.pone.0044907.

175.  Xie J, Wang J, Li R, Dai Q, Yong Y, Zong B, Xu Y, Li E, Ferro A, Xu B.Syndecan-4 over-Expression Preserves Cardiac Function in a Rat Model of Myocardial Infarction', J Mol Cell Cardiol . 2012 Aug;53(2):250-8.

176.  R. Gu, J. Bai, L. Ling, L. Ding, N. Zhang, J. Ye, A. Ferro, and B. Xu.Increased Expression of Integrin-Linked Kinase Improves Cardiac Function and Decreases Mortality in Dilated Cardiomyopathy Model of Rats, PLoS One, 2012;7(2):e31279.

177.  R. Gu, D. Zheng, J. Bai, J. Xie, Q. Dai, and B. Xu.Altered Melusin Pathways Involved in Cardiac Remodeling Following Acute Myocardial Infarction, Cardiovasc Pathol,2012;21(2):105-11.

178.  Gu R, Bai J, Ling L, Ding L, Zhang N, Ye JX, Ferro A, Xu B. Increased expression of integrin-linked kinase improves cardiac function and decreases mortality in dilated cardiomyopathy model of rats. PLoS ONE, 2012,7(2): e31279.

179.  79.Dong L, Kang L, Ding L, Chen Q, Bai J, Gu R, Li L, Xu B.Insulin modulates ischemia-induced endothelial progenitor cell mobilization and neovascularization in diabetic mice. Microvasc Res. 2011 Nov;82(3):227-36.

180.  Xie J, Lu W, Gu R, Dai Q, Zong B, Ling L, Xu B.The impairment of ILK related angiogenesis involves in cardiac maladaptation after infarction. PLoS One. 2011;6(9):e24115.

181.   Gu R, Lu W, Xie J, Bai J, Xu B. Renalase deficiency in heart failure model of rats--a potential mechanism underlying circulating norepinephrine accumulation. PLoS One. 2011 Jan 31;6(1):e14633. doi: 10.1371/journal.pone.0014633.

182.  Ding L, Dong L, Chen X, Zhang L, Xu X, Ferro A, Xu B.Increased Expression of Integrin-Linked Kinase Attenuates Left Ventricular Remodeling and Improves Cardiac Function After Myocardial Infarction. Circulation. 2009;120:764-773.

183.  Zhang J, Ding L, Zhao Y, Sun W, Chen B, Lin H, Wang X, Zhang L, Xu B, Dai J. Collagen-Targeting Vascular Endothelial Growth Factor improves Cardiac Performance After Myocardial Infarction. Circulation. 2009;119:1776-1784.

184.  Kang LN, Chen Q, Wang L, Gao L, Meng K, Chen JH, Ferro A, Xu B. Decreased Mobilization of Endothelial Progenitor Cells Contributes to Impaired Neovascularization in Diabetes. Clin Exp Pharmacol Physiol. 2009 Jun 16.

185.  Chen Q, Dong L, Wang L, Kang L, Xu B. Advanced glycation end products impair function of late endothelial progenitor cells through effects on protein kinase Akt and cyclooxygenase-2. Biochem Biophys Res Commun. 2009 Apr 3.

186.  Li X, Xu B. HMG-CoA Reductase Inhibitor Regulates Endothelial Progenitor Function Through the Phosphatidylinositol 3'-Kinase/AKT Signal Transduction Pathway. Appl Biochem Biotechnol. Appl Biochem Biotechnol. 2009 Jun;157(3):545-53.

187.  Gao L, Kang L, Chen Q, Chen C, Xu B, Jiang S. Advanced glycation end products inhibit production and activity of matrix metalloproteinase-2 in human umbilical vein endothelial cells. J Int Med Res. 2007;35(5):709-715.

188.  Queen LR, Ji Y, Xu B, Young L, Yao K, Wyatt AW, Rowlands DJ, Siow RC, Mann GE, Ferro A.Mechanisms underlying beta2-adrenoceptor-mediated nitric oxide generation by human umbilical vein endothelial cell. hysiol 2006 Jul 27: (Epub ahead of print)

189.  Yao K, Xu B, Gao L, Ge JB.Pravastatin activates platelet nitric oxide synthase(NOS) in patients with type 2 diabets mellitus and NOS activation is accompanied by serine phosphorylation. Chin Med J (Engl). 2005 ;118(19):1654-1657.

190.  Xu B, Ji Y, Yao K, Cao YX, Ferro A. Inhibition of human endothelial cell nitric oxide synthesis by advanced glycation end-products but not glucose: relevance to diabetes. Clin Sci (Lond). 2005;109:439-446.

191.  Xu B, Chibber R, Ruggiero D, Kohner E, Ritter J, Ferro A. Impairment of vascular endothelial nitric oxide synthase activity by advanced glycation end products. FASEB J. 2003;17:1289-1291.

192.  Yao K, Xu B, Liu YP, Ferro A. Effects of beta-adrenoceptor stimulation on endothelial nitric-oxide synthase phosphorylation of human umbilical vein endothelial cells. Acta Pharmacol Sin 2003 Mar; 24(3): 219-224.

193.  Xu B, Xiao-hong L, Lin G, Queen L, Ferro A. Amlodipine, but not verapamil or nifedipine, dilates rabbit femoral artery largely through a nitric oxide- and kinin-dependent mechanism. Br J Pharmacol. 2002;136:375-382.

194.  Xu B, Rao MR. High concentration of glucose inhibits endothelium-dependent vasorelaxation of rabbit aortic artery. Acta Pharmacol Sin, 2001; 22: 861-864. 

195.  Xu B, Li J, Gao L, Ferro A. Nitric oxide-dependent vasodilatation of rabbit femoral artery by beta(2)-adrenergic stimulation or cyclic AMP elevation in vivo. Br J Pharmacol. 2000;129:969-974. 

196.  96.Queen LR, Xu B, Horinouchi K, Fisher I, Ferro A. beta(2)-adrenoceptors activate nitric oxide synthase in human platelets. Circ Res. 2000;87:39-44.

197.  Xu B, Zhang SL, Chen RX. Effects of verapamil on down-regulation of norepinephrine-  induced beta adrenoceptors in cultures rat cardiomyocytes. Acta Pharmacol Sin 1998;19: 148-150.

198.  Xu B, Huang Y. Different mechanisms mediate vasorelaxation of coronary and femoral arteries  by beta adrenoceptor stimulation. Acta Pharmacol Sin 2000;21:309-312

199.  Beta adrenoceptor-mediated vasorelaxation is largely mediated  through the L-arginine/nitric oxide system in human umbilical vein(Abstract). J Physiol 1998; 506: 30P- 31P.

200.  Effect of clonidine on plasma norepinephrine, angiotension II, platelet aggregation rate and platelet cytoplasma-free calcium in hypertensive patients. Chin J  Hyperten 1996; 4(1):61-64

201.  Ferro A, Queen LR, Priest RM, Xu B, Ritter JM, Poston L, Ward JP. Activation of nitric oxide synthase by beta2 adrenoceptors in human umbilical vein endothelium in vitro. Br J Pharmacol 1999; 126: 1872-1880.

202.  Advanced glycation end products impair endothelium-mediatedvasorelaxation in rabbit aortae(Abstract). J Physiol 1998; 511: 167P.

203.  Xu B, Chen RX, Chen DG. Increased pressor responsiveness of femoral arteries to exogenous norepinephrine in renal hypertensive dogs mediated through alpha2 adrenoceptors. Acta Pharmacol Sini 1993;14:229-231.

204.  Xu B, Chen RX, Chen DG, Zhang L, Li JM. Modulation of norepinephrine release in sympathetic nerve endings in renalhypertensive dogs.Acta Phamacol Sini 1990; 11:438-441.

2022年，纳米药物防治急性缺血再灌注损伤的作用与机制研究，国家重点研发计划“十四五”“纳米前沿”重点专项，项目编号2022YFA1205904，456.8万

2022年，血管多模态医学影像信息采集与融合技术的研究，江苏省前沿引领技术基础研究专项前沿项目，课题编号BK20222002，900万

2020年，基于抗炎策略的间充质干细胞外泌体治疗急性心梗心肌缺血再灌注损伤的研究，国家自然科学基金-面上项目，课题编号82070366，55万.

2017年，江苏省医学重点学科，江苏省卫生和计划生育委员会，200万

2016年，经皮梗死血管综合血栓清除治疗急性心梗的临床研究，江苏省科技厅社会发展项目（重大项目）BE2016607，400万

2015年，PAK3在心肌肥大中的作用和机制研究，国家自然基金面上项目，81470371，73万

2014年，心肌细胞再生的基础和应用研究，南大太阳成tyc9728省分子医学重点实验室，4万

2013年，南京心血管病临床医学中心，南京市卫生和计划生育委员会，1000万

2013年，Cdx2+胎盘干细胞移植治疗急性心肌梗塞的实验研究，国家自然科学基金面上项目，81270281，70万

2012年，急性心肌梗死的规范化诊治的流程和新技术的建立及应用，江苏省临床医学科技专项，BL2012014，200万

2011年，转ILK基因治疗终末期心脏病，江苏省卫生厅医学领军人才和领军团队，LJ201153，300万

2011年，转ILK基因治疗终末期心脏病的基础研究，南大中央高校重点项目，1114021402，20万

2010年，心肌高表达ILK对心力衰竭心功能的影响及其机制研究，国家自然科学基金面上项目，81070195，32万

2009年，移植转染ILK基因的干细胞治疗急性心梗疗效和机制研究，省科技厅自然基金，BK2009036，8万

2008年，糖尿病组织缺血后血管新生障碍的基础和临床研究，科技局国际合作，200801121，10万

2007年，糖尿病血管新生障碍的基础和临床研究，卫生厅兴卫工程，RC2007001，100万

2006年，心脏干细胞的基础和临床研究，人事厅六大人才高峰项目，5万

2006年，心脏干细胞的基础和临床研究，科技局社会发展，200601057，3万

2004年，糖尿病动脉粥样硬化斑块不稳定性增加的分子机制，省科技厅自然基金，BK2004083，7.5万

2003年，急性心肌梗塞血管内超声消融的基础和临床研究，卫生局重点项目，ZKX0316，30万

化学消融治疗射频消融无效的顽固性室性心动过速（2023, 江苏省医学新技术二等奖，排名第一）

基于纳米技术与再生医学的冠心病分层个体化诊疗策略的建立与应用（2023江苏医学科技奖青年科技奖，排名第五）

酒精消融治疗射频消融无效的顽固性室性心动过速（2021年，南京市医学新技术一等奖，排名第一）

新一代准分子激光经皮冠脉斑块消蚀术（2020年，江苏省医学新技术一等奖，排名第一）

新一代准分子激光经皮冠脉斑块消蚀术（2019南京市卫生与健康新技术特等奖，排名第一）

证书单位：南京市健康委员会

心力衰竭发生发展的分子靶点探索和应用基础研究（2019年江苏省科技进步二等奖，排名第一））。证书单位：江苏省人民政府

利用系统评价及荟萃分析方法探索并解决心血管介入及药物治疗临床问题（2019年，江苏医学科技一等奖，排名第一）。证书单位：江苏省医学会

左室重构的分子机制和干预靶点的研究（2018年，中华医学科技奖三等奖，排名第一）证书单位：中华医学会

左室重构的分子机制和干预靶点的研究（2017年，江苏省医学科技奖一等奖，排名第一）。证书单位：江苏省医学会

主动脉内球囊反搏支持下联合血管内超声指导行左主干钙化病变旋磨及药物支架植入术（2017年，江苏省医学新技术一等奖，排名第一）。证书单位：江苏省卫生和计划生育委员会

促进EPC动员治疗心肌梗死的临床新技术应用（2014年，江苏省医学新技术引进一等奖，排名第一）。证书单位：江苏省卫生和计划生育委员会

糖尿病血管功能障碍的基础及临床研究（2013年，江苏医学科技奖一等奖，排名第一）。

糖尿病血管功能障碍的基础及临床研究（2013年，江苏省科技进步奖三等奖，排名第一）。

糖尿病血管功能障碍的基础及临床研究（2013年，南京市科技进步奖二等奖，排名第一）。

高血压交感神经活性异常增高的机制（铁道部科技进步三等奖，排名第一）。

高效液相色谱电化学法测定去甲肾上腺素(NE)及其在心血管病的研究和临床应用（铁道部科技进步四等奖，排名第三）

中枢神经和周围神经α受体在高血压发病机制中的作用（福建省科技进步三等奖，排名第四）